Research

One of the major research programs at the Florida Hospital Center for Thrombosis Research focuses on the relationship between the coagulation system and the growth and spread of cancer. Our scientists have published many papers in this area since the program at Florida Hospital began in 1994. The goal of this program is to elucidate the complex relationship between the coagulation system and malignant disease with the aim of developing novel cancer treatments and tumor markers.

The Florida Hospital Center for Thrombosis Research also has a research program that is focused on the mechanisms of thrombosis, antibody-mediated platelet activation, and the detection of hypercoagulable states. This program aims to develop new methods for thrombosis risk assessment in patients with cancer, cardiovascular disease and other disorders.
Projects in these areas include:

The role(s) of tumor cell Tissue Factor in blood-borne metastasis and primary tumor growth
The effects of anticoagulant and anti-platelet drugs on tumor metastasis
The role of procoagulant microparticles in cancer-associated thrombosis and other disorders
Platelet activation by therapeutic monoclonal antibodies
Detection and significance of autoantibodies to platelet CD40L
Development and application of thrombin generation assays