Original Articles
2009
Blaydes S, Langer F, Walker JM, Meyer TV, Robson T, Amaya M, Desai H, Francis JL and Amirkhosravi A.Deficiencies in the CD40 and CD154 receptor-ligand system reduce experimental lung metastasis. Clinical and Experimental Metastasis (in press).
Haubold K, Rink M, Spath B, Friedrich M, Kyoung-Hwan Chun F, Marx G, Amirkhosravi A, Francis JL, Bokemeyer C, Eifrig B, Langer F. Tissue factor procoagulant activity of plasma microparticles is increased in patients with early-stage prostate cancer 101: 1147-1155, 2009. Read the abstract.
Levine RL, Hergenroeder GW, Funk R, Miller, III CC, Hursting, and Francis JL. Heparin-platelet factor 4 antibodies in neurotrauma, shock-trauma, and medical intensive care patients: An observational study of prevalence, incidence, risk factors, and adverse outcomes (submitted for publication).
Meyer TV, Robles-Carrillo, Robson T, Langer F, Desai H, Davila M, Amaya M,. Francis JL and Amirkhosravi A. Bevacizumab immune complexes activate platelets and induce thrombosis in FCGR2A transgenic mice. Journal of Thrombosis and Hemostasis 7: 171-181, 2009. Read the abstract.
2008
Davila M, Amirkhosravi A, Coll E, Desai H, Robles L, Colon J, Baker C and Francis JL. Tissue factor-bearing microparticles derived from tumor cells: impact on coagulation activation. Journal of Thrombosis and Haemostasis 6: 1517-1524, 2008. Read the abstract.
2007
Francis JL, Drexler, A, Duncan MK, Walker J, Hursting M and Levine RL. Heparin-Platelet Factor 4 antibodies in patients presenting to the Emergency Department American Journal of Emergency Medicine 25: 279-284, 2007. Read the abstract.
Langer F, Chun KHF, Amirkhosravi A, Friedrich M, Leuenroth S, Elfrig B, Bokemeyer C, Huland H and Francis JL. Plasma tissue factor antigen in localized prostate cancer: distribution, clinical significance, and association with platelet activation markers. Thrombosis and Haemostasis 97: 464-470, 2007. Read the abstract.
Langer F, Steinmetz O, Marx G, Amirkhosravi A, Eifrig B, Bokemeyer C, Brümmendorf T. Aprotinin-induced hemolytic thrombotic microangiopathy in a patient with acute myelogenous leukemia (AML) and systemic coagulopathy. American Journal of Hematology 82: 1122-1124, 2007.
2006
Biggerstaff J, Weidow B, Amirkhosravi A and Francis JL. Enumeration of leukocyte infiltration in solid tumors by confocal laser scanning microscopy. BMC Immunology 7: 16, 2006. Read the abstract.
Drexler AJ. Investigator-Initiated Research Projects 101. The Monitor, 20: 45-49, 2006.
Langer F, Amirkhosravi A, Ingersoll SB, Walker JM, Spath B, Eifrig B, Bokemeyer C and Francis JL. Experimental metastasis and primary tumor growth in mice with hemophilia A Journal of Thrombosis and Haemostasis 4: 1-8, 2006.
Mousa SA, Linhardt R, Francis JL and Amirkhosravi A. Anti-metastatic effect of non-anticoagulant low molecular weight heparin versus standard low molecular weight heparin Thrombosis and Haemostasis 96: 816-821, 2006. Read the abstract.
2005
Francis JL and Hursting MJ. Effect of argatroban on the APTT. Blood Coagulation & Fibrinolysis 16: 251-257, 2005.
Langer F, Ingersoll S, Amirkhosravi A, Meyer T, Siddiqui F, Ahmad S, Walker JM, Amaya M, Desai H and Francis JL. The role of CD40 in CD40- and antibody-mediated platelet activation. Thrombosis and Haemostasis 93: 1137-1146, 2005.
Mosquera LA, Card KF, Price-Schiavi SA, Belmont HJ, Liu B, Builes J, Zhu X, Chavaillaz PA, Lee HI, Jiao JA, Francis JL, Amirkhosravi A, Wong RL, Wong HC. In Vitro and In Vivo Characterization of a Novel Antibody-Like Single-Chain TCR Human IgG1 Fusion Protein. Journal of Immunology, 174: 4381-4388, 2005.
2004
Card KF, Price-Schiavi SA, Liu B, Thomson E, Nieves E, Belmont H, Builes J, Jiao JA, Hernandez J, Weidanz J, Sherman L, Francis JL, Amirkhosravi A, Wong HC. A soluble single-chain T-cell receptor IL-2 fusion protein retains MHC-restricted peptide specificity and IL-2 bioactivity. Cancer Immunol Immunother. 53: 345-57, 2004.
Langer F, Ali Amirkhosravi A, Loges S, Meyer T, Eifrig B, Hossfeld DK, Fiedler W and Francis JL. An In Vitro Study on the Mechanisms of Coagulation Activation in Acute Myelogenous Leukemia (AML): Role of Tissue Factor Regulation by Cytotoxic Drugs and GM-CSF. Thrombosis and Haemostasis 92: 1136-1146, 2004.
Levine RL, Hursting MJ, Drexler A, Lewis BE and Francis JL. Heparin-induced thrombocytopenia in the Emergency Room. Annals of Emergency Medicine 44: 511-515, 2004.
2003
Francis, JL. An algorithmic approach to laboratory diagnosis of thrombotic risk factors. Laboratory Hematology 9: 82-83, 2003.
Amirkhosravi A, Mousa SA, Amaya M, Blaydes S, Desai H, Meyer T and Francis JL. Inhibition of tumor cell-induced platelet aggregation and lung metastasis by the oral GpIIb/IIIa antagonist XV454. Thrombosis and Haemostasis 90:549-554, 2003.
Amirkhosravi A, Mousa SA, Amaya M and Francis JL. Anti-metastatic effect of tinzaparin, a low molecular weight heparin. Journal of Thrombosis and Hemostasis 1: 1972-1976, 2003.
Francis JL, Palmer GJ, Moroose R and Drexler A. Comparative effects of bovine and porcine heparin on heparin antibody formation following cardiovascular surgery. Annals of Thoracic Surgery 75:17-22, 2003.
Siddiqui FA, Siddiqui TF and Francis JL. Hemoglobin Induces the production and release of matrix metalloproteinase-9 from human malignant cells. Blood Coagulation & Fibrinolysis 14: 449-455, 2003.
Palmer JD, Francis JL, Pickard JD and Ianotti F. The efficacy and safety of aprotinin for hemostasis intracranial surgery. Journal of Neurosurgery 98:1208-1216, 2003.
2002
Amirkhosravi A, Amaya M, Desai, and Francis JL. Platelet CD40 ligand interaction with melanoma cell and monocyte CD40 enhances cellular procoagulant activity. Blood Coagulation & Fibrinolysis 13: 505-512, 2002.
Amirkhosravi A, Meyer T, Chang J-Y, Amaya M, Siddiqui F, Desai H and Francis JL. Tissue factor pathway inhibitor reduced experimental lung metastasis of B16 melanoma. Thrombosis and Haemostasis 87: 930-936, 2002.
Rice L, Attisha WK, Francis JL and Drexler A. Delayed Onset Heparin-Induced Thrombocytopenia. Annals of Internal Medicine 136: 210-215, 2002.
Siddiqui FA and Francis JL. Hemoglobin binds melanoma cell tissue factor and enhances its procoagulant activity. Blood Coagulation & Fibrinolysis 13: 178-180, 2002.
Siddiqui FA, Desai H, Amirkhosravi A, Amaya M, Francis JL. The presence and release of tissue factor from human platelets. Platelets 13: 247-253, 2002.
Siddiqui FA, Desai H, Siddiqui TF and Francis JL. Hemoglobin induces the expression and secretion of vascular endothelial growth factor from human malignant cells. The Haematology Journal 3:264-270, 2002.
2001
Siddiqui F, Amirkhosravi A, Amaya M, Meyer T, Biggerstaff JP and Francis JL. Hemoglobin Enhances Tissue Factor Expression on Human Malignant Cells. Blood Coagulation & Fibrinolysis 12: 171-177, 2001.
Siddiqui F, Amirkhosravi A, Amaya M, Meyer T and Francis JL. Purification and properties of human melanoma cell tissue factor. Clinical and Applied Thrombosis / Hemostasis. 7: 289-295, 2001.
2000
Francis JL. Platelet dysfunction detected at high shear in patients with heart valve disease. Platelets 11, 133-136, 2000.
Lwaleed BA, Francis JL and Chisholm M. Urinary tissue factor levels in patients with bladder and prostate cancer. Eur J Surg Oncol 26: 44-49, 2000.
Lwaleed BA, Francis JL and Chisholm M. Monocyte tissue factor levels in cancer patients. Saudi Medical Journal 8: 722-729, 2000.
1999
Francis JL. Performance Characteristics of the Optical and Mechanical Measuring Modes on the AMAX 190 Coagulation Analyzer. Clinical Hemostasis Review 13: 6-9, 1999.
Francis JL, Francis DA, Larson L, Helms E and Garcia M. Can the Platelet Function Analyzer (PFA)-100 substitute for the template bleeding time in routine clinical practice? Platelets 10: 132-136, 1999.
Lwaleed BA, Francis JL and Chisholm M. Monocyte tissue factor levels in patients with urological tumors: an association between tumor presence and progression. British Journal of Urology 83: 476-482, 1999.
Lwaleed BA, Bass PS, Francis JL and Chisholm M. Functional and structural properties of urinary tissue factor. Nephrology, Dialysis and Transplantation 14: 588-596, 1999.
Lwaleed BA, Bass PS, Chisholm M and Francis JL. Urinary tissue factor: A potential marker of disease. The Journal of Pathology 188: 3-8, 1999.
Lwaleed BA, Chisholm M, and Francis JL. The significance of measuring monocyte tissue factor activity in patients with breast and colorectal cancer. British Journal of Cancer 80: 279-285, 1999.
Lwaleed BA, Bass PS, Chisholm M and Francis JL. Development and validation of an assay for urinary tissue factor activity. Journal of Clinical Pathology 52: 219-224, 1999.
Larson L, Helms E, Garcia M, Farris T, Moroose R and Francis JL. Heparin-induced thrombocytopenia and thrombosis. Laboratory Medicine 30: 642-645, 1999.
Amirkhosravi A, Amaya M, Siddiqui F, Biggerstaff JP, Meyer TV and Francis JL. Blockade of GpIIb/IIIa inhibits the release of vascular endothelial growth factor (VEGF) from tumor-activated platelets and experimental metastasis. Platelets 10: 285-292, 1999.
Lwaleed BA, Chisholm M and Francis JL. Urinary tissue factor in patients with breast and colorectal cancer. Journal of Pathology 187: 291-294, 1999.
Lwaleed BA, Chisholm M and Francis JL. Tissue factor assays as diagnostic tools for cancer? Correlation between urinary and monocyte tissue factor activity. J Hematother.Stem.Cell Res. 8: 659-668, 1999.
Biggerstaff JP, Seth A, Amirkhosravi A, Amaya M, Fogarty S, Meyer TV, Siddiqui FA and Francis JL. Soluble fibrin augments platelet-tumor cell adherence in vitro and in vivo and enhances experimental metastasis Clinical Experimental Metastasis 17, 723-730, 1999.
1998
Amirkhosravi A, Meyer M, Warnes G, Malik Z, Biggerstaff JP, Siddiqui FA, Sherman P and. Francis. JL Pentoxifylline inhibits hypoxia-induced upregulation of tumor cell tissue factor and vascular endothelial growth factor. Thrombosis and Haemostasis 80, 598-602, 1998.
Biggerstaff JP, Seth NB, Meyer A, Amirkhosravi A and Francis JL. Fibrin monomer increases adherence to tumor cells in a flowing system: A possible role in metastasis? Thrombosis Research 92: (Suppl 2): S52-S58, 1998.
Kumar S, Reed MW, Gamper HB Jr, Gorn VV, Lukhtanov EA, Foti M, West J, Meyer RB Jr, Schweitzer BI. Solution structure of a highly stable DNA duplex conjugated to a minor groove binder. Nucleic Acids Research 26: 831-838, 1998.
Lwaleed BA, Bass PS, Rogerson ME, Francis JL and Chisholm M. The effect of kidney function and disease status on urinary tissue factor measurements. Journal of Clinical Pathology, 51: 234-237, 1998.
Shao W, Jerva LF, West J, Lolis E, Schweitzer BI. Solution structure of murine macrophage inflammatory protein-2. Biochemistry 37:8303-8310, 1998.
Warnes G, Biggerstaff JP and Francis JL. Monocyte B7 and Sialyl Lewis X modulates the efficacy of IL-10 down-regulation of LPS-induced monocyte tissue factor in whole blood British Journal of Haematology, 102, 588-596, 1998.
1997
Amirkhosravi A, Warnes G, Biggerstaff JP, Malik Z, May K and Francis JL. The effect of pentoxifylline on spontaneous and experimental metastasis of the mouse neuro2a neuroblastoma. Clinical and Experimental Metastasis 15: 453-461, 1997.
Biggerstaff JP, Amirkhosravi A and Francis JL. Three dimensional visualization and quantitation of fibrin in solid tumors by confocal laser scanning microscopy. Cytometry 29, 122-127, 1997.
Foti M, Marshalko SJ, Beardsley GP and Schweitzer BI. Solution structure of a DNA decamer containing the antiviral agent ganciclovir: Determination by two-dimensional homonuclear and heteronuclear NMR, restrained molecular dynamics, and complete relaxation matrix analysis. Biochemistry, 36, 5336-5345, 1997.
Francis JL, Garcia M and Helms E. Coronary artery occlusion in a young man. Case of the Month. Clinical Hemostasis Review 11: 22, 1997.
Lwaleed BA, Bass PS, Chisholm M and Francis JL. Urinary tissue factor levels in glomerulonephritis: a potential marker of glomerular injury? Journal of Clinical Pathology 50: 336-340, 1997.
Meyer T, Garcia M, Helms E, Francis DA and Francis JL. Temporal changes in the activated protein C resistance ratio in a heterozygote for FV Leiden are abolished by dilution in FV-deficient plasma. Clinical & Applied Thrombosis/Hemostasis 3: 99-101, 1997.
Ranaboldo CJ, Thompson JF, Davies JN, Shutt AM, Francis JL, Roath OS, Webster JHH and Chant ADB. Prospective randomized placebo-controlled trial of aprotinin for elective aortic reconstruction. British Journal of Surgery 84: 1110-1113, 1997.
1996
Amirkhosravi A, Biggerstaff JP, Warnes G, Francis DA and Francis JL. Determination of tumor cell procoagulant activity by SonoclotÔ analysis in whole blood. Thrombosis Research 84: 323-332, 1996.
Amirkhosravi M, Alexander M, May K, Warnes, G, Biggerstaff JP, Francis DA and Francis JL. Importance of platelets in monocyte tissue factor expression assessed in a novel whole blood flow cytometric assay. Thrombosis and Haemostasis 75: 87-95, 1996.
Callihan D, West J, Schweitzer BI and Logan TM. Simple, distortion-free homonuclear spectra of peptides and nucleic acids in water using excitation sculpting. Journal of Magnetic Resonance, Series B, 112, 82-86, 1996.
1995
Amirkhosravi M, Francis JL. Coagulation activation by MC28 fibrosarcoma cells facilitates lung tumor formation, Thrombosis and Haemostasis 73: 59-65, 1995.
Francis JL, Carvalho M and Francis DA. Diagnostic value of tissue factor measurements. Blood Coagulation & Fibrinolysis 1995; 6: Suppl. 1: 1995.
Francis JL. Effects of aprotinin on white cells and hemostasis. In: Blood Conservation with Aprotinin. (Ed: Roque Pifarre), Hanley and Belfus, Philadelphia, 1995
Palmer JD, Francis DA, Roath OS, Francis JL and Iannotti F. Hyperfibrinolysis during intracranial surgery: Effect of high dose aprotinin. Journal of Neurology, Neurosurgery and Psychiatry 58: 104-106, 1995.
Schweitzer BI, Gardner KH and Tucker-Kellogg G. HeteroTOCSY-based experiments for measuring heteronuclear relaxation in nucleic acids and proteins. Journal of Biomolecular NMR 6, 180-188, 1995.
Segal HC, Hunt BJ, Cottam S, Baird C, Francis JL, Potter D, Tan KC. Changes in the contact system during orthotopic liver transplantation with and without aprotinin. Transplantation 59: 366-370, 1995.
1994
Adamson AS, Luckert P, Pollard M, Snell ME, Amirkhosravi M, Francis JL. Procoagulant activity may be a marker of the malignant phenotype in experimental prostate cancer. British Journal of Cancer 69, 286-290, 1994.
Francis JL, DA Francis, G Gunathilagan. Assessment of hypercoagulability in patients with cancer using the Sonoclot Analyzer and Thromboelastography. Thrombosis Research 74, 335-346, 1994.
Segal HC, Hunt BJ, Cottam S, Baird C, Francis JL, Potter D, Tan KC. Fibrinolytic activity during orthotopic liver transplantation with and without aprotinin. Transplantation 58: 1356-1360, 1994.
